role of the transfer-messenger rna pathway _ trans-translation _ in bacterial physiology

tmrna (also known as ssra or 10sa rna) is so-named for its dual nature so that can function like trna and mrna. tmrna involved in a trans-translation reaction that truly is a kind of translational quality control system. this process contributes to the recycling of stalled translation complexes at the end of an mrna lacking a stop codon or at an internal mrna cluster of rare codons in a process termed “ribosome rescue”. this review focuses on the mechanism of ribosome rescue and the role of this unique bi-functional rna in bacterial physiology. moreover, recent studies suggest that the tmrna inactivation may be a useful therapeutic target to increase the sensitivity of pathogenic bacteria against antibiotics so tmrna pathway could be a useful target for antibiotic development.